Related Papers
Cancer
Fertility preservation in children, adolescents, and young adults with cancer: Quality of clinical practice guidelines and variations in recommendations
2016 •
Eline Broeder
Fertility Preservation and Adolescent Cancer Patients: Lessons from Adult Survivors of Childhood Cancer and Their Parents
Laurie Zoloth
Building on 40 years of progress in cancer detection and treatment, survival rates for childhood cancers have risen from 20 % to almost 80 % [1,2]. Approximately 270,000 Americans are childhood cancer survivors and, by 2010, an estimated 1 in every 250 adults will be living with a history of childhood cancer [2,3]. The early and late effects of treatment are beginning to take on greater importance for survivors, their families and providers [4]. Increasing numbers of childhood cancer survivors are beginning to face a new challenge in returning to normalcy after cancer.
Frontiers in Oncology
Fertility Preservation in Female Pediatric Patients With Cancer: A Clinical and Regulatory Issue
2021 •
Lucia Gozzo
Fertility preservation represents one important goal of cancer patients’ management due to the high impact on health and quality of life of survivors. The available preventive measures cannot be performed in all patients and are not feasible in all health-care facilities. Therefore, the pharmacological treatment with GnRHa has become a valuable non-invasive and well-tolerated alternative, especially in those who cannot access to cryopreservation options due to clinical and/or logistic issues. Supporting data demonstrate a significant advantage for the survivors who received GnRHa in the long-term maintenance of ovarian function and preservation of fertility. The prevention of the risk of ovarian failure with GnRHa is a typical off-label use, defined as the administration of a medicinal product not in accordance with the authorized product information. Italy has officially recognized the off-label use of GnRHa in adult women at risk of premature and permanent menopause following chem...
The Lancet Oncology
Communication and ethical considerations for fertility preservation for patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group
2021 •
Jill Ginsberg
Human Reproduction Update
Fertility preservation for girls and young women with cancer: what are the remaining challenges?
2010 •
Richard Anderson
European journal of gynaecological oncology
Combination of fertility preservation strategies in young women with recently diagnosed cancer
Igor Crha, Martin Huser, Petr Janku
The study describes clinical management and outcomes of currently available fertility preservation techniques in a set of 154 young female cancer patients. Patients in reproductive age with newly diagnosed cancer were offered embryo or oocyte cryopreservation, ovarian tissue cryopreservation and the administration of GnRH analogues during chemotherapy. Particular attention was given to the technical aspects and clinical application of these fertility preservation techniques. During the study period (2004-2009), 154 young female cancer patients were offered fertility preservation counseling. Patient's average age was 29.4 years and average parity was 0.7 children. Administration of GnRH analogues (n = 123, 79.9%) and ovarian tissue cryopreservation (n = 15, 9.7%) were the most commonly used fertility preservation strategies. In 20 cases (16.1%), the combination of several fertility preservation techniques was offered to individually selected patients. Combination of fertility pre...
Urology
Fertility Preservation in Children and Adolescents With Cancer
2016 •
Marzena Samardakiewicz
Journal of the National Comprehensive Cancer Network
Optimizing Fertility Preservation Practices for Adolescent and Young Adult Cancer Patients
Rebecca Johnson
Textbook of Oncofertility Research and Practice
Childhood, Adolescent, and Young Adult Cancer: Fertility Implications and Clinical Practice
2019 •
Barbara Lockart
Survival rates in childhood and adolescent cancer have risen over the past decades, leading to the potential for desiring a family as a survivor. Young adults with cancer (patients diagnosed between ages of 15 and 39) are a recognized group of patients with special needs including fertility preservation and access to care. These patient groups together are referred to Childhood, Adolescent and Young Adult (CAYA) oncology and have been a focus in oncofertility since its inception. Research on outcomes of gonadal toxicity from cancer treatment modalities has been abundant and led to practitioners being proactive as standards of care have changed to address fertility-preserving options at diagnosis or at relapse of disease. Ethical issues and access to these services have been a concern in the younger population of CAYA cancer patients. Infertility and sterility have been known to cause psychological distress, and healthcare providers need to be aware of this and trained to address fer...
Pediatrics
Fertility Preservation for Pediatric and Adolescent Patients With Cancer: Medical and Ethical Considerations
2020 •
Sigal Klipstein
Many cancers presenting in children and adolescents are curable with surgery, chemotherapy, and/or radiotherapy. Potential adverse consequences of treatment include sterility, infertility, or subfertility as a result of gonad removal, damage to germ cells as a result of adjuvant therapy, or damage to the pituitary and hypothalamus or uterus as a result of irradiation. In recent years, treatment of solid tumors and hematologic malignancies has been modified in an attempt to reduce damage to the gonadal axis. Simultaneously, advances in assisted reproductive technology have led to new possibilities for the prevention and treatment of infertility. This clinical report reviews the medical aspects and ethical considerations that arise when considering fertility preservation in pediatric and adolescent patients with cancer.
